# Long-term durability of DENV-specific immunity after vaccination in a dengue-endemic population

> **NIH NIH U01** · UNIVERSITY OF RHODE ISLAND · 2024 · $567,169

## Abstract

Abstract
 The goal of this FOA is “to improve our understanding of how vaccines against infectious agents
lead to durable protective immunity.” This project seeks to address this objective through a detailed
characterization of immune responses in the early phase post-vaccination to identify components that
distinguish durable from non-durable responses to vaccination with a live attenuated vaccine against
dengue virus (DENV). To date, a single dengue vaccine (CYD-TDV) has reached licensure and others
have shown promising efficacy data, but there remain important gaps in the safety and efficacy of these
vaccines, particularly around the issue of the durability of protective immunity. This project leverages
blood samples available from dengue vaccine trials, in particular a longitudinal study of participants from
a phase III trial of CYD-TDV that has been ongoing since 2011. The project addresses the overall
hypothesis that functional, transcriptomic, and epigenetic profiles of DENV-specific T and B lymphocytes
early post-vaccination predict the establishment of long-lasting DENV-specific serologic immunity
through the following Specific Aims: 1) Identify T and B cell functional responses to DENV associated
with the long-term persistence of binding and neutralizing antibodies after receipt of CYD-TDV; 2) Identify
gene expression and epigenetic profile(s) in DENV-specific T and B lymphocytes associated with the
persistence of antibodies after receipt of CYD-TDV; and 3) Validate the immunological signature of
durable antibody responses in recipients of CYD-TDV and compare this signature to other dengue
vaccines and to natural and experimental DENV infection.

## Key facts

- **NIH application ID:** 10764620
- **Project number:** 1U01AI179523-01
- **Recipient organization:** UNIVERSITY OF RHODE ISLAND
- **Principal Investigator:** Alan L Rothman
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $567,169
- **Award type:** 1
- **Project period:** 2024-03-06 → 2029-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10764620

## Citation

> US National Institutes of Health, RePORTER application 10764620, Long-term durability of DENV-specific immunity after vaccination in a dengue-endemic population (1U01AI179523-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10764620. Licensed CC0.

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