# Quantitative Systemic Studies of Bacterial Physiology

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $605,017

## Abstract

Project Summary
This research will significantly expand the PI’s unique research program in quantitative bacterial physiology from the
exclusive focus on the model organism Escherichia coli during the past decade to a variety of species across the bacterial
phylogeny, including Vibrio, Pseudomonas, Bacteroides, Mycobacterium, and Bacillus. Transcriptomic, proteomic, and
metabolomic approaches will be applied to these bacterial species for a spectrum of conditions with emphasis on cementing
absolute abundances of the measured quantities as well as the rate of synthesis and turnover. For each species investigated,
we will replicate previous studies for E. coli to derive both coarse-grained phenomenological models as well as establish
relation to molecular regulation. We will also develop methods for inter-species comparisons at the quantitative level. These
studies will not only generate a vast amount of useful quantitative data and models for bacteria of

## Key facts

- **NIH application ID:** 10764648
- **Project number:** 1R35GM152133-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** TERENCE HWA
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $605,017
- **Award type:** 1
- **Project period:** 2024-03-01 → 2029-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10764648

## Citation

> US National Institutes of Health, RePORTER application 10764648, Quantitative Systemic Studies of Bacterial Physiology (1R35GM152133-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10764648. Licensed CC0.

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