# Maintenance of an SPF Macaque Breeding Colony for AIDS Research

> **NIH NIH U42** · TULANE UNIVERSITY OF LOUISIANA · 2024 · $1,415,801

## Abstract

Project Summary/Abstract - Overall
The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies
in the United States. The objective of this application is to request funds for continued support and maintenance
of the U42 supported SPF Indian-origin rhesus monkey breeding colony at the TNPRC. Production will be
moderately increased in the next few years based on recent developments in funding and animal demand. The
specific aims address the components specified in the funding opportunity announcement (FOA) and are divided
into the Overall program description, Husbandry and Management Core, Viral Testing Core, and MHC Genetic
Typing Core. Program income and TNPRC funds will be used to support components of the program not covered
by grant funds including: per diem for any colony animals in excess of the animals supported by this application,
additional testing required for those animals, infrastructure repairs and improvements, veterinary clinical and
pathology support, behavioral management support, and portions of the genetic testing.
Specific Aims:
Overall. To maintain the existing SPF colony and distribute available animals to the NIH funded HIV/AIDS
research community.
Husbandry and Management Core. To provide husbandry and veterinary care for the SPF breeding colony
established in the existing U42 grant. This includes a robust program for clinical veterinary medical care and
behavioral management. The colony has reached a mature self-sustaining status with ideal demographics to
produce up to 150 animals available for assignment each year. Program income generated by the animal sales
will be returned to an account for use in supporting the aims of the grant.
Viral Testing Core. To assure the SPF status of the colony through continued viral testing of existing breeding
colony animals and all offspring. Continue to expand characterization of the colony beyond the required 4 viruses
to include agents such as measles virus, SARS CoV2, Trypanosoma cruzi, and other emerging infectious
diseases that threaten nonhuman primates.
MHC Genetic Typing Core. To continue genetic analysis and MHC typing of the colony and provide expanded
genetic characterization through enhanced techniques.

## Key facts

- **NIH application ID:** 10764697
- **Project number:** 5U42OD010568-22
- **Recipient organization:** TULANE UNIVERSITY OF LOUISIANA
- **Principal Investigator:** KASI E RUSSELL-LODRIGUE
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,415,801
- **Award type:** 5
- **Project period:** 2001-08-09 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10764697

## Citation

> US National Institutes of Health, RePORTER application 10764697, Maintenance of an SPF Macaque Breeding Colony for AIDS Research (5U42OD010568-22). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10764697. Licensed CC0.

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