# Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease

> **NIH NIH R01** · NORTHEAST OHIO MEDICAL UNIVERSITY · 2024 · $584,539

## Abstract

Project Summary
Project Summary: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide. The pathogenic mechanism remains incompletely understood. Bile acids (BAs) are endocrine
hormones that are important for the biological processes. Dysregulation of BA metabolism may cause
cholestasis, liver cancer, NAFLD, etc. Activation of BA receptors FXR and TGR5 has been shown to protect
against NAFLD in mice and clinical trials. Transmembrane protein 141 (TMEM141) belongs to the TMEM protein
family that consists of proteins of mostly unknown functions. So far, nothing is known about the biological
functions of TMEM141. In this project, we plan to investigate the role of hepatic TMEM141 in the pathogenesis
of NAFLD. We will investigate whether and how hepatic TMEM141 regulates the development of NAFLD and
bile acid metabolism, and how hepatic TMEM141 expression is regulated in NAFLD. We will use a number of
genetically modified mice and a complementary approach to accomplish our goals.

## Key facts

- **NIH application ID:** 10764914
- **Project number:** 5R01DK102619-07
- **Recipient organization:** NORTHEAST OHIO MEDICAL UNIVERSITY
- **Principal Investigator:** Yanqiao Zhang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $584,539
- **Award type:** 5
- **Project period:** 2015-07-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10764914

## Citation

> US National Institutes of Health, RePORTER application 10764914, Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease (5R01DK102619-07). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10764914. Licensed CC0.

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