# Origins, Functional, and Evolutionary Consequences of Genomic Variation

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2024 · $444,647

## Abstract

Project Summary
Genetic variation is the central component of all major evolutionary processes. Differences among individuals’
genomes contribute to phenotypic variation including disease susceptibility and the evolution of adaptation.
The exceptional growth in genome sequencing technologies and concomitant acceleration in the development
of bioinformatic software has the potential to address longstanding questions about the evolution of genomes.
Our lab will continue to lead this scientific endeavor by developing a range of statistical, computational, and
experimental techniques. In particular, we will develop uniquely scalable computational methods to infer and to
understand the relationships among densely sampled populations such as SARS-CoV-2. We will develop
computational techniques to study adaptation and the underpinning of genetic isolation using genomes from
admixed populations. Our group will leverage an established genome engineering technique to rearrange parts
of genomes that have remained structurally static for more than 100 million years and to determine what
molecular and fitness effects underlie this maintenance. Finally, our team will leverage natural variation in
intron abundance to determine the molecular consequences and fitness impacts of massive intron gain.
Results from this work have profound implications for understanding the origins, effects, and ultimate
consequences of genetic variation on evolutionary outcomes in natural populations.

## Key facts

- **NIH application ID:** 10765475
- **Project number:** 2R35GM128932-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA SANTA CRUZ
- **Principal Investigator:** Russell Corbett-Detig
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $444,647
- **Award type:** 2
- **Project period:** 2018-08-01 → 2028-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10765475

## Citation

> US National Institutes of Health, RePORTER application 10765475, Origins, Functional, and Evolutionary Consequences of Genomic Variation (2R35GM128932-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10765475. Licensed CC0.

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