# Clinical Core

> **NIH NIH U19** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $586,149

## Abstract

PROJECT SUMMARY / ABSTRACT
 CLINICAL CORE
The broad long-term objective of the UM BACPAC MRC Clinical Core will be to provide an enduring resource
for the NIH BACPAC initiative. The data collected and cohorts established throughout the course of this project
will remain a resource for a wide array of individuals and entities that conduct clinical pain research. The more
immediate objective of the UM Clinical Core will be to provide the substrate for the successful completion of all
four Specific Aims noted in the Overview for this application. The Interventional Response Phenotyping
research project central to this effort will rely heavily on the patient population, existing registry, and research
infrastructure of the Department of Anesthesiology’s Back and Pain Center at the University of Michigan and
the experienced research team at the Chronic Pain and Fatigue Research Center (CPFRC). Both centers,
working in concert, will make up the UM Clinical Core. The Michigan Medicine Back & Pain Center is a large
tertiary care pain clinic that evaluates over 1500 new patients per year and conducts nearly three times as
many return patient visits The Back & Pain Center has a pain patient registry (>8700) with rich pain
phenotyping data, including numerous PROMIS measures, that are routinely collected from most of the new
patients evaluated each year at the pain clinic. Further, there are nested cohort studies based on the data of
registry patients, as well as randomized controlled trials that draw from them and are managed by the
experienced study personnel. Similarly, the CPFRC has a long and rich history of successfully collecting the
types of deep phenotyping data specified herein (e.g., neuroimaging, quantitative sensory testing [QST],
inflammatory factors, ecological momentary assessment [EMA]) and has been a leader in the field of pain
research for close to two decades. The UM Clinical Core will tap into our existing infrastructure and well-
phenotyped patient population and address the following aims. First, the UM Clinical Core will provide the
infrastructure and resources for the baseline assessment and both light and deep phenotyping data collection
including the processing and analysis of neurobiological samples. Second, it will support the Interventional
Response Phenotyping study through the recruitment, enrollment and retention of patient participants with
chronic low back pain. Third, the UM Clinical Core will support the provision of the SMART design study
interventions to be used in the Interventional Response Phenotyping study. Lastly, the clinical core will
coordinate with the Informatics Core and Algorithm Development and Operations Management Center (DAC)
for data management, statistical analysis and data sharing.

## Key facts

- **NIH application ID:** 10765815
- **Project number:** 4U19AR076734-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Afton L Hassett
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $586,149
- **Award type:** 4N
- **Project period:** 2019-09-26 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10765815

## Citation

> US National Institutes of Health, RePORTER application 10765815, Clinical Core (4U19AR076734-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10765815. Licensed CC0.

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