# CReATE Motion Center:  Cartilage Regeneration using Advanced Technologies to Enable Motion

> **NIH VA I50** · PHILADELPHIA VA MEDICAL CENTER · 2024 · —

## Abstract

This proposal will establish a new Center at the Corporal Michael J. Crescenz VA Medical Center (CMCVAMC)
in Philadelphia focused on Cartilage Regeneration using Advanced Technologies to Enable Motion
(CReATE Motion). This new initiative builds upon the extensive scientific foundation, outstanding infrastructure,
and thriving educational and mentoring programs that we have established within the musculoskeletal programs
at the CMCVAMC in the Translational Musculoskeletal Research Center (TMRC) and through our collaborations
with the Atlanta VA Medical Center (AVAMC). The CReATE Motion Center will include investigators with
expertise in musculoskeletal regeneration, pain, cell-based therapies, biomanufacturing, and translational
sciences drawn from Orthopaedic Surgery, Neurosurgery, the Department of Medicine, Bioengineering, and
Physical Medicine & Rehabilitation at the CMC VAMC and the University of Pennsylvania (its primary affiliate)
and the Atlanta VAMC and Emory University (its primary affiliate).
The Mission of our CReATE Motion Center is to develop a translational pipeline for advanced cartilage and
joint regenerative therapies aimed at treating arthritis, joint injuries, and related joint disorders, by cultivating
core infrastructure and building an intellectual critical mass in this area. We will apply this framework to
accelerate the clinical implementation of cutting-edge strategies to restore joint function and transform the
long-term health of our Veterans.
Our new CReATE Motion Center is focused on 3 major interacting research cores (RCs) that support 3 central
research focus areas (RFAs) and our educational and outreach mission. The Research Cores will focus on
Biomanufacturing and Translation (RC1), Rehabilitative Models and Tools (RC2), and Advancing Clinical
Evaluation (RC3). These Cores support the three main CReATE Motion Research Focus Areas, centered on
Molecules and Delivery Systems (RFA1), Cells and Cell Products (RFA2), and Biologic Joint Resurfacing’
(RFA3). CReATE Motion will fund Pilot Awards and Collaborative Exchanges in each of the 3 research focus
areas through a peer-reviewed mechanism. Taken Together, CReATE Motion, with its associated Cores,
Trainee, and Pilot Funding, is designed to produce new knowledge, novel products, and advances in clinical
care, with a specific focus on functional restoration of the musculoskeletal system.
Equally important to advancing the scientific and translational underpinnings of CReATE Motion is the training
of the next generation of VA-focused scientists and clinicians working in this research space and engaging
Veterans. To that end, our Educational and Outreach (E&O) mission includes (1) a Fellowship Program in
Translational Tissue Engineering & Regenerative Medicine (“T-TERM”) to educate trainees and the community
on processes of clinical translation and commercialization, (2) regular Techniques Workshops & Chalk Talks to
increase collaboration and interactions across the Cente...

## Key facts

- **NIH application ID:** 10766048
- **Project number:** 1I50RX004845-01
- **Recipient organization:** PHILADELPHIA VA MEDICAL CENTER
- **Principal Investigator:** Robert L Mauck
- **Activity code:** I50 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2024
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2024-01-01 → 2028-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10766048

## Citation

> US National Institutes of Health, RePORTER application 10766048, CReATE Motion Center:  Cartilage Regeneration using Advanced Technologies to Enable Motion (1I50RX004845-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10766048. Licensed CC0.

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