SHARED RESOURCES MANAGEMENT – PROJECT SUMMARY The mission of the University of Virginia Cancer Center (UVACC) Shared Resources is to provide high quality, value-added support for UVACC Members as aligned with the goals of the UVACC. The management of the Shared Resources is focused on effectively managing the Shared Resources; ensuring that the Shared Resources meet the scientific needs of the UVACC Members; and planning for future directions and needs of the UVACC for Shared Resource support. At the last renewal of the UVACC, seven Shared Resources were submitted including Advanced Microscopy Facility (AMF) (Scored Outstanding to Excellent), Animal Models of Disease Core (AMDC) (Scored Excellent), Bioinformatics Core (BIC) (Scored Very Good to Excellent), Biomolecular Analysis Facility (BAF) (Scored Outstanding), Biorepository and Tissue Research Facility (BTRF) (Scored Very Good to Excellent), Biostatistics Shared Resource (BSR) (Scored Outstanding to Excellent), and Flow Cytometry Core (FCC) (Scored Excellent to Outstanding). In the current submission, the UVACC also proposes seven Shared Resources. However, in response to the requests from UVACC Program Leaders, and based on suggestions from the last review and external reviewers, the UVACC reorganized and enhanced the Animal Models of Disease Core to include additional protocols and technology for studying immune response in cancer and cancer therapy and renamed the core the Molecular and Immunological Translational Sciences Core (MITS). Given that most of the bioinformatics efforts are in association with support of the data-intensive platforms present in the BAF (such as DNA and RNA sequencing, proteomics and metabolomics) the BIC is now embedded within the BAF. To support researchers in the Cancer Control and Population Health Program (CPH), we have added one Shared Resource, the Population Health and Cancer Outcome Core (PHCOC). These changes in structure, along with focused improvements to the Shared Resources per the recommendations of the last review, position the UVACC Shared Resources to provide exceptional expertise, support, and education for Members' pursuit of cancer research as aligned with the mission of the UVACC.