# Phase IIB Plasticity-based Adaptive Cognitive Remediation for Alzheimers Disease

> **NIH NIH R44** · POSIT SCIENCE CORPORATION · 2024 · $867,247

## Abstract

Project Summary Abstract
The primary objectives of the current project are 1) to evaluate the longer-term efficacy of PACR-AD cognitive
training (PACR-CT) measured 5 years after the completion of initial 10 weeks of training, 2) to determine the
efficacy of the 10 weeks of booster training after 5 years from the initial training completion, and 3) to redesign
the PACR-CT for optimal training schedule to sustain and potentially further-grow program-delivered benefits.
We will examine prolonged PACR-CT efficacy compared to Active Control (Casual Games) at 5 years after
training by comparing 1) cognitive and functional performance, 2) structural (white matter integrity and brain
volume) and functional brain changes (rsfMRI and task-fMRI) and 3) neurodegeneration assessed with blood-
based biomarkers (pTau-181) predictive of AD risk. Next, we will examine the general booster efficacy (pre- vs.
post-booster training), and the interaction between initial training and booster training by comparing the change
scores between groups. Finally, we will modify PACR-CT schedule with the optimal booster training interval
calculated based on the rate of natural cognitive decline measured from Aim 1 and the performance
improvement from the 10 weeks of booster training from Aim 2. Evaluation of the longer-term effect PACR-CT
and the booster effect will be used to obtain FDA clearance for the program and commercialize it as the
evidence-based prevention device indicated for age-related cognitive decline. This project should result in the
development of a new, and powerful tool to provide effective adjunctive therapy that results in far greater
resilience against cognitive impairment in a substantially greater pre-AD population.

## Key facts

- **NIH application ID:** 10766753
- **Project number:** 5R44AG047722-08
- **Recipient organization:** POSIT SCIENCE CORPORATION
- **Principal Investigator:** Hyun Kyu Lee
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $867,247
- **Award type:** 5
- **Project period:** 2014-09-30 → 2026-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10766753

## Citation

> US National Institutes of Health, RePORTER application 10766753, Phase IIB Plasticity-based Adaptive Cognitive Remediation for Alzheimers Disease (5R44AG047722-08). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10766753. Licensed CC0.

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