Hematology Research Training Program (T32 HL-07439) PI/PD: Brass, Lawrence F. Abstract The Hematology Research Training Program (HRTP) at the University of Pennsylvania was established in the mid-1970’s. It has received NHLBI T32 funding since 1978 and to date it has provided support for 179 predoctoral and postdoctoral trainees. The program’s mission is to sustain the hematology workforce by providing basic and translational research experiences, training, career advising and mentorship to a diverse group of physician- scientists and scientists. Our goals for the next 5 years include 1) providing the training and mentorship that will allow our graduates to become successful investigators in settings that include academia, industry, federal agencies, and the NIH and other research institutes, 2) helping to grow the research workforce in areas related to hematology, blood cells and blood disorders, and 3) working with other T32-funded hematology research training programs to exchange best practices and allow individual trainees to benefit from a wider network. The current program directors are Lawrence Brass, MD PhD and Ivan Maillard, MD PhD, both of whom are members of Penn’s Hematology-Oncology Division, where Dr. Maillard is the Vice Chief for Research and Dr. Brass directs the MD/PhD program. The diverse participating faculty includes 47 trainers of all academic ranks. Policies are in place for adding or removing trainers from the roster. Participation in mentorship training is expected by all. NHLBI T32 support for the HRTP currently includes 8 clinical fellows and postdocs plus 4 MD/PhD and PhD predocs. Renewed funding is requested at the same level. Participating graduate programs are primarily those within the Biomedical Graduate Studies (BGS) umbrella program, but some trainees will be in the Chemical & Biomolecular Engineering (CBE) program. Key features of the HRTP include formal and informal advising, workshops, attendance at national conferences, and training in the responsible conduct of research and methods to enhance reproducibility. There is a well-received annual presentation and feedback session attended by our Internal and External Advisory Boards, whose membership includes the directors of 5 other T32-funded research training programs. Program outcomes. 143 postdocs (31 MD/PhD, 65 MD and 47 PhD) and 36 predocs (23 MD/PhD and 13 PhD) have been supported to date. Of the 153 who have completed all subsequent stages of training, 76% have positions that we consider appropriate outcomes for alumni of this training program, including 71 (46%) who have full-time appointments at academic institutions or the NIH, and 31 (20%) who are employed in the biotech and pharmaceutical industries. In this proposal we present a plan for attracting, training and mentoring a diverse group of individuals, monitoring their progress during training, and tracking their journeys afterwards. A logic model and rubric have been developed to allow us to comb...