PROJECT SUMMARY—Data Collection and Clinical Genetics Core The Program entitled “Genetic Variation in Cancer Risk and Outcomes in African Americans” comprises three Research Projects and two Shared Resource Core components (Administration, and Data Collection and Clinical Genetics). The Data Collection and Clinical Genetics Core provides a shared platform for the identification of eligible Detroit Research on Cancer Survivors (ROCS) study participants for all Projects, provides existing ROCS data for all projects, supports large scale recruitment and data collection for Project 2 using the ROCS framework, collects new and manages existing biospecimens for sequencing and genotyping including quality control on returned genetic data, and links patient data to the Metropolitan Detroit Cancer Surveillance System (MDCSS) cancer registry for clinical cancer data, the occurrence of multiple primary cancers and recurrence/survival outcomes. The Core will ensure consistency in the use of previously collected data and biospecimens and reliability in incorporating/linking these data with newly collected, Project-specific survey and genetic data and biospecimens across the three projects and four participating institutions. The Core will also provide access to clinical genetics testing services for those participants who, based on research-based testing, carry clinically actionable mutations or are included in Project 3. With these resources, we have the opportunity to address genetic variation in a population-based study of African Americans with cancer and improve uptake of genetic testing that will ultimately lead to improved outcomes and a reduction in cancer disparities.