PROJECT ABSTRACT Advanced studies in cardiovascular research innovation are increasingly requiring multi-disciplinary studies that include mathematical, computation, and engineering principles. Likewise, translation of novel discoveries requires clinical knowledge, and a solid foundation in the understanding of vascular pathophysiology. The future in cardiovascular research innovation will depend on successful partnerships between problem solvers comprised of clinician-investigators and engineers. The fundamental premise of this training program is that early engagement of post-graduate surgical trainees and pre-graduate engineering doctoral students will help accelerate development of technology and solutions for the diagnosis, treatment, and prevention of cardiovascular diseases. Research topics will include cardiac arrhythmia, coronary artery disease, peripheral vascular (arterial/venous) disease, aortic aneurysmal disease, and neurovascular disease. With a highly diverse and accomplished faculty mentorship network, high-level of institutional support, and already well- established multi-disciplinary research between surgery and engineering at Washington University in St. Louis, we propose a training program that will develop common synergistic skillsets in translational research and engineering towards solving common and difficult problems in this field. Graduates of this novel training program will have the knowledge and expertise to pursue either an academic or research-related career in the diagnosis, management, and/or prevention of cardiovascular diseases.