# Effect of aging and senescent cells

> **NIH NIH P01** · UNIVERSITY OF MINNESOTA · 2024 · $539,772

## Abstract

Project Summary
The goal of this proposal is to understand how aging and senescent cells impact resident memory T cell
differentiation, longevity, and functional interactions with individual tissue cell types, including parenchymal,
stromal, innate and adaptive immune cells. Single cell assays will address gaps in understanding of resident
memory T cell dialogue with resident hematopoietic and non-hematopoietic cells in both mouse and humans.
The impact of the age of the organism, the age of the T cell, or targeted elimination of senescent cell populations
will be tested as isolated variables. This study will inform mechanisms of immune disfunction in the elderly and
therapeutic opportunities for rejuvenating tissue immunity.

## Key facts

- **NIH application ID:** 10767639
- **Project number:** 1P01AI172501-01A1
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** DAVID MASOPUST
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $539,772
- **Award type:** 1
- **Project period:** 2024-03-11 → 2029-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10767639

## Citation

> US National Institutes of Health, RePORTER application 10767639, Effect of aging and senescent cells (1P01AI172501-01A1). Retrieved via AI Analytics 2026-08-12 from https://api.ai-analytics.org/grant/nih/10767639. Licensed CC0.

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