Biostatistics Shared Resource Summary Proper and efficient statistical design and analysis is critical to the conduct of rigorous and reproducible studies. The mission of the Biostatistics Shared Resource is to provide state-of-the-art services in the planning, conduct, analysis, and reporting of cancer-related basic science studies, population science studies, and clinical science studies—especially clinical trials. The mission is achieved through the following specific aims: 1) To support and collaborate with Masonic Cancer Center researchers on all activities, at all stages related to the preparation of grant applications; 2) To support and collaborate with Masonic Cancer Center researchers on the execution of all stages of funded research projects; 3) To support the design and data analyses of all studies, whether funded externally, internally, partially funded by departments, or even unfunded; 4) To support and implement quality assurance and data management plans for all collected data; and 5) To support and participate in protocol design, monitoring, and reporting through collaboration with the Clinical Trials Office and participation in the Cancer Protocol Review Committee and the Data Safety and Monitoring Committee. The Biostatistics Shared Resource provides consultation and education to Cancer Center members and their trainees in Basic, Population, and Clinical Sciences in preparing grant applications. It ensures that all experimental designs, study monitoring, and data analyses take advantage of robust and efficient methods that reflect best practices in biostatistics and supports the activities of the Clinical Trials Office. The Shared Resource was used by 86 individuals in fiscal year 2022, 60 of whom were Cancer Center members. The Biostatistics Shared Resource is led by Dr. Chap T. Le (Transplant and Cellular Therapy Program). It is currently staffed by 8 faculty members, including Dr. Le (3 Full Professors, 2 Associate Professors, and 3 Assistant Professors) and 6 master’s-level research fellows and senior research fellows. During the current funding cycle, we were able to expand the Biostatistics Shared Resource from 11 to 14 members; we have maintained stable leadership and can offer Cancer Center members well-organized and well-coordinated support. The quality of our service benefits from specialization, with each member focusing on a limited number of technical areas and research programs; continuing education, with master’s-level staff encouraged to audit courses on new topics; and oversight of staff by senior statisticians who provide advice, mentoring, and monitoring. Weekly meetings provide time to discuss technical issues in addition to operational issues. Therefore, the Biostatistics Shared Resource makes significant contributions to the quality of research in the Masonic Cancer Center.