ABSTRACT: Despite what are truly modern miracles of science, diagnostics and therapeutics, cardiovascular disease remains an immense human and societal burden. The objective of this longstanding training grant is to prepare the next generation of MD and PhD scientists for careers in cardiovascular disease research, for positive impact on the field. An astounding 90% of prior trainees from the last two cycles have careers which involve research, and many prior trainees from past T32 grant cycles have become academic cardiovascular leaders across the country. The Program consists of ten educational opportunity “Pods” spanning a range of topic areas from translational to clinical and clinical and population science. These Pods provide trainees with cohesive research opportunities in (1) cardiovascular aging; (2) vascular biology / thrombosis / inflammation; (3) ion channel biology & arrhythmia; (4) cardiovascular genetics; (5) population/clinical science; (6) cardiac myocyte biology / myopathies; (7) cardiovascular disease in women; (8) multiomics and system biology (including metabolism); (9) heart and brain health; and (10) digital health. These latter two Pods represent new and expanded training opportunities to leverage major new institutional programs, and several of the original Pods have been expanded/reorganized. The grant, now in its 24th year, provides both didactic training as well as research immersion for MD, MD PhD, or PhD trainees. It has trained a large number of investigators, many of whom have led paradigm-changing and sustained research programs and have trainees of their own. Many of the recent trainees have obtained NIH K- or even R-level funding, with 67% remaining in academia and 23% having secured industry positions. The T32 core leadership team consists of three senior faculty, each of whom has a substantial portfolio of research and training, who are drawn from the fields of vascular biology, cardiovascular pharmacology, and cardiometabolic disease. The program is integrated with common didactic coursework including a grant-writing workshop, instruction in the responsible conduct of research, and a diverse array of topical scientific seminars. The glue which holds this program together as a cohesive whole is the purposeful interactions of trainees at Division-sponsored trainee luncheons, and an interactive networking program that facilitates interchange among trainee peers and preceptors. Trainees are guided in their individual didactic programs and experiential learning in labs (bench or computational) with a regular cadence of meetings with T32 Program Executive leadership, as well as a Trainee Advisory Committee. Metrics for success include coursework completion, public data presentations, publications, and preparation of an individual (mock or real) training grant subjected to internal review and feedback. An innovation for this program includes interaction of trainees with a group of less senior but highly accomplished...