# Core B: Molecular Pathology and Bioinformatics Core

> **NIH NIH P01** · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $689,119

## Abstract

CORE B ABSTRACT
Molecular Pathology and Bioinformatics Core
Core Director: Michael Berger, PhD (MSK)
The Molecular Pathology and Bioinformatics Core will work closely with all Project teams to coordinate the
procurement and analysis of patient-derived tumor and matched normal tissue prioritized for further
characterization to fulfill the Research Aims. Biospecimens from selected patients will be obtained from
participating AACR GENIE sites and characterized centrally by the Core. Digital pathology imaging and nucleic
acid extraction will be performed from FFPE tissue specimens using standardized protocols. Comprehensive
genomic platforms, including whole exome sequencing and RNA-Seq, will be run under the direct supervision
of the Core Director to enable deeper, multi-omic characterization of samples previously tested using targeted
DNA panels. State-of-the-art bioinformatics pipelines will be used to produce and disseminate results to Project
teams, and Core members will collaborate with each Project to provide customized analytics support directed
to the individual Aims.

## Key facts

- **NIH application ID:** 10768980
- **Project number:** 1P01CA275746-01A1
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** Michael F. Berger
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $689,119
- **Award type:** 1
- **Project period:** 2024-09-03 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10768980

## Citation

> US National Institutes of Health, RePORTER application 10768980, Core B: Molecular Pathology and Bioinformatics Core (1P01CA275746-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10768980. Licensed CC0.

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