Project Summary The Administrative Core is led by Drs. Panagiotis Konstantinopoulos, Joyce Liu, and Ursula Matulonis who are in addition the Principal Investigators (PI)/Program Directors (PD’s) of this resubmitted P01 grant. The Administrative Core will provide organizational leadership and administrative management of this P01 grant, monitor the progress of Projects, and coordinate the internal and external communication amongst the Projects and Cores within the P01 grant. The structure of this P01 grant will allow close supervision and monitoring oversight of all Projects and Cores equally by Drs. Konstantinopoulos, Liu, and Matulonis. The Administrative Core Leaders will monitor projects through regularly scheduled meetings with all of the Project and Core leaders, teams, and key investigators and will interface with a very accomplished External Advisory Board (EAB), Internal Advisory Board (IAB) and advocates. The EAB and IAB will review the progress made on the specific aims, accrual to clinical trials if applicable, results of specific experiments outlined in the grant, abstracts and publications as well as pitfalls or roadblocks that have occurred. The Administrative Core leaders will also be responsible and accountable for the proper conduct of the project or program including the submission of all required reports and will also share fiscal and resource oversight of this grant. The Administrative Core will also be responsible for integration and collaboration within this Endometrial Cancer P01 grant and to ensure seamless and effective communication within this P01 grant as well as external dissemination of the results. The Administrative Core will also integrate the Projects and other Cores across DFCI, the Brigham and Women’s Hospital, as well as the Dana-Farber/Harvard Cancer Center. Communication of results within the P01 grant team and externally will be facilitated by this Administrative Core and will be the responsibility of this Core. Drs. Konstantinopoulos, Liu and Matulonis will assist investigators in this endometrial cancer P01 grant to publicly disclosed results at academic meetings.