PROJECT SUMMARY The Biostatistics and Computational Biology Core will provide comprehensive statistical, bioinformatics and computational biology support for all three projects and for the Preclinical Modeling and the Pathology Cores. The Core Leader, Dr. Nabihah Tayob, and other members of the Core team will bring in the statistical and computational biology expertise required for experimental design, pre-clinical and clinical studies, as well as data collection, management, integration, and quality control. The core has identified key areas where the members of the core will collaborate with project investigators and core leaders to ensure integrated and comprehensive biostatistical support to the entire P01 program. The primary role of the Biostatistics and Computational Biology Core is to provide biostatistics and computational biology expertise for the design, conduct, monitoring, analysis, and reporting of laboratory, animal, translational, clinical studies and including associated correlative studies. The Biostatistics and Computational Biology Core will also provide input on data collection, management and integration and assist investigators in coordinating laboratory results with outcomes from clinical studies or clinical/translational research databases and work with investigators to develop new statistical methods to address problems arising in endometrial cancer research for which no standard methodologies are available.