# Biospecimen Core

> **NIH NIH P50** · JOHNS HOPKINS UNIVERSITY · 2024 · $275,102

## Abstract

Project Summary/Abstract: The primary goal of the Biospecimen/Pathology Core B is to facilitate
translational research related to prostate tissue-based studies. The major functions of the core are to collect,
annotate, provide quality control/quality assurance measures, develop standard operating procedures, catalog
specimens within databases, improve operations, and test and implement new technologies for interrogating
biomarkers in tissue-based studies. Core B has appropriate informatics capabilities for tracking biospecimens,
as well as linkage to clinical follow-up data sets. For the majority of our specimens in the repository, the
essential pathological, clinical and family history information is available. In addition, we utilize FFPE cell line
tissue blocks from cells with known genetic features as well as cell line tissue microarray’s (TMAs); these serve
as standardized reference specimens for biomarker validation studies. Core B has a well-established history of
supplying tissues and their derivatives to multiple investigators, performing immunohistochemical workups and
staining protocols, testing and implementing new immunohistochemical and in situ hybridization technologies,
performing research on biospecimens to determine optimal methods for preparations of DNA, RNA and
protein. New functions have been and are being further developed for laser capture microdissection of frozen
metastatic prostate cancer biopsies for genomic studies, and of FFPE tissues for immune-oncology studies
relevant to the Research Projects in the current SPORE application. These include implementation of
HALO™ algorithms for quantifying AR and MYC as well as specific inflammatory cell types in tumors using
singleplex and multiplex IHC and Digital Spatial Profiling for protein and high content RNA studies. The core
has also collaborated with and shared tools and biospecimens with many other investigators both within and
outside the SPORE program, both within our institution as well as a number of others throughout the country.

## Key facts

- **NIH application ID:** 10769308
- **Project number:** 1P50CA272391-01A1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** ANGELO Michael DE MARZO
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $275,102
- **Award type:** 1
- **Project period:** 2024-09-01 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10769308

## Citation

> US National Institutes of Health, RePORTER application 10769308, Biospecimen Core (1P50CA272391-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10769308. Licensed CC0.

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