PROJECT SUMMARY – INTEGRATIVE GENOMICS AND BIOINFORMATICS The Integrative Genomics and Bioinformatics Shared Resource (IGC) provides analytical, computational, and technical services for all types of -OMICS (e.g., genomics, metabolomics and proteomics) research performed by Salk Cancer Center (SCC) members. In the era of big data in biology, bioinformatics analysis is crucial for deriving biological insights from large and noisy high-throughput data. The goal of the IGC has been to provide SCC members access to state-of-the-art bioinformatics expertise and support. Staff in the IGC assist SCC members with integrative analysis of sequencing datasets, provide software and tools that SCC members can use to perform their own analyses, provide training in software use, and develop customized tools and pipelines for cutting-edge analyses. As needed, they also develop new tools and techniques for SCC members whose projects push the boundaries of research, generate publication quality visualizations of analyses, and help prepare scientific manuscripts and grants containing bioinformatics or genomics components. The IGC is used by 20 SCC members (65%) accounting for 49% of the services utilized.