# Rat Resource and Research Center

> **NIH NIH P40** · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $1,300,192

## Abstract

Abstract (Overall)
The mission of the Rat Resource and Research Center (RRRC) is to provide biomedical investigators with the
rat models, embryonic stem cells, related reagents, protocols, information, support and services that will facilitate
their research. The RRRC serves as a unique repository by importing, storing and distributing a large number of
rat strains/stocks. It assures that valuable models are preserved and made available to interested investigators,
allows researchers to satisfy NIH requirements for resource sharing, relieves individual investigators from the
burden of animal distribution and ensures that models are maintained with rigorous genetic quality control and
health monitoring to promote experimental rigor and reproducibility. Recent advances in genome editing
technologies are facilitating the ability to perform sophisticated genetic modifications in rats in order to study both
normal biological processes and disease states. As a result, the number of rat models and the number of
investigators using rat models for biomedical research is increasing and the RRRC, as one of the only centralized
repositories in the world will continue to serve a critical role for archiving and distributing these new models. To
improve repository functions, applied research to optimize methods for sperm cryopreservation and in vitro
fertilization in the rat will be undertaken and ongoing efforts to refine, generate and characterize new genetically
modified rat models needed by the research community will be performed. To expand the broad utility of the
RRRC, we will continue to serve as consultants to the community and we will increase our fee-for-services in
the areas of model generation, model characterization, colony management, cryopreservation and rederivation.
By providing accessible expertise to investigators working with rats and by expanding our available materials
and services, the RRRC will continue to serve as a much-needed “one stop” resource for investigators using rats
in biomedical research.

## Key facts

- **NIH application ID:** 10769744
- **Project number:** 5P40OD011062-24
- **Recipient organization:** UNIVERSITY OF MISSOURI-COLUMBIA
- **Principal Investigator:** Elizabeth C Bryda
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,300,192
- **Award type:** 5
- **Project period:** 2001-06-01 → 2026-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10769744

## Citation

> US National Institutes of Health, RePORTER application 10769744, Rat Resource and Research Center (5P40OD011062-24). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10769744. Licensed CC0.

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