Summary The Biomedical Data Sets and Services Core (BDSSC) of this COBRE will be established to expand services and expertise provided beyond federal datasets to encompass all types of data utilized by the Research Project Leaders (RPLs) who will be supported by this Phase 1 COBRE and future iterations. The BDSSC’s primary innovation will be linking biomedical, environmental, and health records data to survey data that collects demographic, marital status, family structure, education, and employment data to understand how behavior, environment and biology combine to influence health outcomes. The BDSSC will achieve these goals with the specific aims of: 1) assisting RPLs with data discovery and procurement for project development; 2) building analysis datasets and providing statistical analysis for project execution; and 3) expand core productivity to support COBRE stakeholders including RPLs, mentors, new faculty and other biomedical and social science researchers. Building on the success of the BDSSC, researchers at KU and across our region will have access to a new resource to support additional biomedical research funding in the ever-advancing field of complex data science. As of now, no data services center exists at KU or in the region. The BDSSC will create research capacity not currently available on campus to support data-intensive research across the biomedical, behavioral, health, and social sciences to support fundamental research designed to improve health outcomes.