mPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience
type: Grant
alternate name: 5P50AA010761-29
description: SUMMARY With advances in opto-/chemo-genetic stimulation techniques, preclinical studies have demonstrated that activity in frontal-striatal neural circuits has a causal influence on heavy alcohol drinking and relapse-like behavior. Similar findings using modern fMRI imaging techniques in humans have confirmed some of these findings. Clinically, however, we have not yet translated this research into a neural circuit based therapeutic technique for patients with alcohol use disorder (AUD). The long term goal of our multidisciplinary research team is to determine the optimal parameters through which non-invasive transcranial magnetic stimulation (TMS) can be used to improve alcohol drinking outcomes (abstinence, heavy drinking days) among individuals seeking behavioral treatment for AUD. Building on a foundation of several TMS brain target identification studies and a small double-blinded clinical trial in treatment-engaged AUD patients performed by our group in the Charleston Alcohol Re
amount: MonetaryAmount
  value: 196261
  currency: USD
funder: NIH — NIH
funder alt: US National Institutes of Health
recipient: MEDICAL UNIVERSITY OF SOUTH CAROLINA
start date: 1996-12-01
end date: 2025-12-31
license: https://creativecommons.org/publicdomain/zero/1.0/
source: https://reporter.nih.gov/project-details/10771173
source organization: NIH RePORTER
publisher: AI Analytics
keywords: P50
keywords: NIH
keywords: 5

AI Analytics
type: Organization