PROJECT SUMMARY Women and adolescent girls of South Asian background experience multilevel barriers to physical activity (PA). The South Asians Active Together (SAATH) trial (R01CA242520) is an ongoing randomized controlled trial that has enrolled 172 South Asian (SA) American mothers and adolescent daughters to evaluate the effects of a dyadic physical activity (PA) intervention on moderate to vigorous PA in SA women and girls. The goal of this administrative supplement to the SAATH trial is to conduct new research to identify and develop replicable strategies to overcome gender-specific barriers that South Asian women experience to clinical research participation. Our team has extensive experience with community-engaged recruitment of South Asian Americans in clinical research; however, SA women and girls remain underrepresented in PA and cancer prevention research despite persistent health disparities. Even with community-engaged recruitment approaches, there are strong differences between male and female participants regarding access to opportunities and multilevel influences on the decision to participate in clinical research. The research proposed in this supplement targets knowledge gaps about the influence and intersection of gender and ethnicity on implementation strategies to improve representation of SA women in clinical research. Specific Aims of this Administrative Supplement are to: 1) Identify how gendered roles, experiences, and identities influence access, participation, and inclusion as research subjects by performing and analyzing semi- structured interviews with SA mothers and daughters who did and did not participate in the SAATH trial (n=15 dyads); 2) Develop and evaluate replicable strategies using an intersectional lens and participatory action model for enhancing access and inclusion of SA women and adolescent girls in PA and cancer prevention research. This administrative supplement is led by Principal Investigator (PI) Namratha Kandula, MD, MPH and includes an early stage investigator, Milkie Vu, PhD who will be mentored by the Dr. Kandula to accomplish the scientific goals of the parent study and supplement. This administrative supplement will address Objective 1.2, Objective 2.4, and Objective 3.1of the Trans-NIH Strategic Plan for Women's Health Research, which seek to investigate the influence of sex and gender on disease prevention, presentation, management, and outcomes, improve the recruitment and retention of women underrepresented in clinical research, and disseminate and implement evidence-based strategies to improve women's health. Results new commitment from this supplement will provide knowledge about the intersection of gender and ethnicity to inform replicable strategies to improve of SA women and adolescents girls for future PA and cancer prevention studies.