# Hazardous Waste Thermal Treatment and Community Exposure to Environmentally Persistent Free Radicals

> **NIH NIH P42** · LOUISIANA STATE UNIV A&M COL BATON ROUGE · 2024 · $210,707

## Abstract

Project Summary/Abstract: Project 3
Nearly 53 million people live within 3 miles of a Superfund remediation site. Superfund sites contain a wide va-
riety of pollutants, including organic chemicals, metals, carbonaceous material, and silica. Although each com-
ponent is capable of damage to organisms, their potential to combine into unique hazardous agents has been
understudied. Interestingly, when these agents are present together, particularly during thermal treatment (TT),
they combine to form particulate matter (PM) with chemisorbed free radicals that persist in the environment
and are active in biological systems (environmentally persistent free radicals: EPFRs). EPFRs are produced
during TT of hazardous wastes. Nearly 30% of all Superfund sites (non-groundwater) are remediated by TT.
EPFR concentrations near Superfund sites range from 1x1018–4x1019 radicals/g of PM. Colfax, LA hosts a haz-
ardous waste TT facility, which disposes of fireworks, explosives, and military ordnances. 68% of Colfax’s resi-
dents are African American and median household income is $26,149, indicating the community’s institutional
vulnerability. Project 3 will measure concentrations of EPFRs to estimate human exposure in Colfax. We will
also measure other components of combustion-generated PM across size fractions and detonation-related
noise as a co-stressor. Project 3 addresses the three overarching objectives of the 2018 Strategic Plan for the
Superfund Research Program. By characterizing EPFRs emitted from this TT site handling hazardous wastes
including waste from Superfund sites, we address an issue of high relevance to inform solution-oriented re-
search. We will maximize the impact of our program’s investments by coordinating with the Research Transla-
tion component of the Administrative Core to facilitate translation of our results to actionable information for the
Colfax community. Further, we will coordinate with the Community Engagement Core (CEC) to implement our
community-based participatory research model. This novel approach will foster innovation by designing and
implementing a field sampling plan for size distributions of EPFRs, size distributions of other PM components,
and noise as a co-stressor. The overarching hypothesis of this research is that EPFRs are produced in meas-
urable quantities in PM during TT, so that outdoor and in-home EPFR exposure increases with decreasing dis-
tance to the source. In Aim 1, we will partner with the Colfax community on plans for assessing exposure to
hazardous air pollutants from hazardous waste TT emissions and determine if collaboration will promote com-
munity empowerment and engagement on public health advocacy. This work is planned in partnership with two
community organizations and in coordination with the CEC. Aim 2 will characterize Colfax residents’ exposures
to EPFRs in PM by size distribution and composition, how exposures change with distance downwind of the TT
facility, and how exposures correla...

## Key facts

- **NIH application ID:** 10772195
- **Project number:** 5P42ES013648-12
- **Recipient organization:** LOUISIANA STATE UNIV A&M COL BATON ROUGE
- **Principal Investigator:** Jennifer Richmond-Bryant
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $210,707
- **Award type:** 5
- **Project period:** 2009-08-15 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10772195

## Citation

> US National Institutes of Health, RePORTER application 10772195, Hazardous Waste Thermal Treatment and Community Exposure to Environmentally Persistent Free Radicals (5P42ES013648-12). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10772195. Licensed CC0.

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