CORE A – ADMINISTRATION PROJECT SUMMARY The Administrative Core provides services that are critical to every member of the Program. This Core is the administrative and organizational structure that the Principal Investigator uses to effectively manage and oversee the entire Program. Core A supports an administrator for this Program Project as well as significant support for a biostatistician. The administrator organizes the interactions between the Principal Investigator and any collaborators who are not members of this Program Project. The administrator also assists the Principal Investigator with management of the budgets, and acts as a liaison between the CSHL administrations. The research administrator may also assist individual Project leaders with administrative tasks, including manuscript preparation and submission of non-competing continuation reports. The Administrative Core serves as the Program archive, collecting and storing published papers and all other Program related materials. This ensures that all Program publications be placed into the public domain via PubMed Central. The Core A administrator and/or bioinformatics personnel assist in depositing large datasets to the appropriate repository upon publication (e.g., GEO for next-gen sequencing or array datasets). Core A also is responsible for organizing interactions with both an internal and external advisory committee to advise the Principal Investigator and Project Leaders on strategies and approaches, as well as planning for the future.