# Administration Core

> **NIH NIH P41** · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $260,570

## Abstract

The intersection of healthcare and biomedical research is at an inflection point with the convergence of
cancer biology combined with new personalized therapies, the digital revolution, nanotechnology, big data
science, and precision or personalized medicine. There is a wealth of meaningful information and
knowledge that could be extracted from imaging data, but is currently not fully accessible by clinicians and
hence cannot be optimally utilized for patient care, procedures or surgery. Medical care providers are
constantly inundated with increasing amounts of patient data (both relevant and not) which are increasing
in complexity. Cancer care exemplifies the current clinical challenges which include early detection,
accurate distinction of pre-neoplastic and neoplastic lesions, determining infiltrative tumor margins during
surgical treatment, tracking tumor evolution and potential acquired resistance to treatments over
time, and prediction of tumor aggressiveness, metastasis pattern, and recurrence. Major strides have
been made in the personalization of cancer therapies such as immunotherapy but the availability of
specific, relevant, and timely medical data and information is of critical importance to realizing the full
potential of precision medicine. Nowhere is this more acutely evident than during medical/surgical
interventions in the operating and procedure rooms. Novel methods of imaging cancer to investigate the
microstructure and inherent heterogeneity, image guidance, data integration, information extraction, and
knowledge transfer are critical to inform and enable clinicians to fully leverage the information available,
especially before, during and after invasive procedures. We are excited to propose this revised P41
biomedical resource center (BTRC) called Advanced Technologies for NCIGT or AT-NCIGT with 3 TRDs,
10 CP’s & 10 SPs. The 3 components, which we will investigate and develop new technology for are:
Imaging Cancer heterogenity, Deep Learning and Intraoperative devices for image guided therapy.
The BTRC will be organized with senior level experienced team led by the PI, assisted by TRD PI’s and
others. They will support all research activities, ensure CP/SP support and review and mentor junior
investigators and trainees. The overall goal of this proposal is to investigate, develop, and disseminate
novel advanced technologies such as new MR sequences for tissue characterization-Imaging Cancer
Heterogeneity (TR&D 1); analyze them and make them available through state-of-the- art algorithmic and
data curation approaches (Deep Learning TR&D 2); and development of a set of comprehensive
intraoperative planning, guidance and monitoring technologies and devices ( Intraoperative devices for
image guided therapy TR&D 3). We will disseminate all innovations and specific deliverables to the CPs
and SPs through the established mechanisms of the National Center for Image Guided Therapy
(NCIGT), which continues to be dedicated to the inves...

## Key facts

- **NIH application ID:** 10773070
- **Project number:** 5P41EB028741-04
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** CLARE M TEMPANY
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $260,570
- **Award type:** 5
- **Project period:** 2021-01-06 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10773070

## Citation

> US National Institutes of Health, RePORTER application 10773070, Administration Core (5P41EB028741-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10773070. Licensed CC0.

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