# Resource Component

> **NIH NIH U42** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2023 · $595,316

## Abstract

Resource
PROJECT SUMMARY / ABSTRACT
The overarching goal of the Resource Component of the Center for Somatic Cell Genome Editing in
Nonhuman Primates is to provide nonhuman primates (wild-type, reporter, disease models) in the quantity and
quality necessary to meet the needs of investigators. The Resource Component is embedded within the
established, comprehensive infrastructure provided by the California National Primate Research Center with a
range of standard operating procedures (SOPs) and Quality Assurance/Quality Control (QA/QC) functions to
ensure that the goals and objectives are met under the highest quality standards. Nonhuman primates will be
screened and selected by the Testing Center using established SOPs for studies conducted in the Genome
Editing and Biological Effects Testing Component that will evaluate efficiency, specificity, safety, and
immunogenicity of the technologies proposed. The Coordination Component will ensure an integrated
approach across all components of the Testing Center. The Resource Component will accelerate translation of
somatic cell genome editing technologies from studies in nonhuman primates into treatments for human
diseases through the following Specific Aims: (1) Provide high quality animals across age groups for somatic
cell genome editing studies, and (2) Screen and select nonhuman primates to evaluate somatic cell genome
editing technologies. The Resource Component will ensure investigators have the quality and quantity of
nonhuman primates necessary across all age groups. Males and females will be included in study cohorts, and
sample size selected to ensure statistically significant data, as well as rigor and reproducibility. Paired with the
Genome Editing and Biological Effects Testing Component, and within the context of the infrastructure of the
UC Davis California National Primate Research Center, the Resource Component will deliver the animals and
conduct the procedures necessary to comprehensively assess the promise of new somatic cell genome editing
technologies for the future treatment of human disease.

## Key facts

- **NIH application ID:** 10773950
- **Project number:** 1U42OD035737-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Alice F Tarantal
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $595,316
- **Award type:** 1
- **Project period:** 2023-09-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10773950

## Citation

> US National Institutes of Health, RePORTER application 10773950, Resource Component (1U42OD035737-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10773950. Licensed CC0.

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