# Exploring the role of genomic repeats in cardiovascular disease heritability

> **NIH NIH K25** · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $156,600

## Abstract

PROJECT SUMMARY/ABSTRACT
This project aims to explore the genetic component of cardiovascular diseases contributed by repeats in
human genomes. Cardiovascular diseases, the leading cause of death in the US, have sizeable genetic
components which remain unexplained by association studies. Recent studies of coronary artery disease,
ischemic stroke, and atrial fibrillation explain less than a quarter of the heritability in these diseases observed in
family studies. The gap between observed and explained heritability has persisted despite large increases in
the sample sizes in genome-wide association studies. This ‘missing heritability’ hinders the understanding of
the genetic basis for cardiovascular disease, and the development of genetically-informed therapies.
A potential contributor to the missing heritability is structural variation in genomes, which is usually omitted
from association studies. Genetic association studies typically focus on single nucleotide polymorphisms
(SNPs)—i.e., single base pair changes—and do not account for structural variants—i.e., mutations affecting
large stretches of the genome. Structural variants are difficult to resolve using short-read sequencing or array-
based genotyping technologies. While structural variants are rarer than SNPs, they are responsible for more
base pairs of variation per individual due to their large length.
The proposed research program will quantify and characterize the cardiovascular impact of variable number
tandem repeats (VNTRs), an understudied class of structural variants in which a specific nucleotide sequence
is repeated a varying number of times in different individuals. The human genome contains thousands of
VNTR regions, a few of which are already known to influence common diseases. The proposed research will
leverage existing genotyped cohorts consisting of hundreds of thousands of individuals to conduct a systematic
study of the role of VNTR length variation in cardiovascular diseases. These cohorts are genotyped using
arrays which do not directly assay VNTR lengths. The PI will develop statistical methods to impute VNTR
lengths into large cohorts, and characterize the contribution of VNTR variation to cardiovascular disease.
Additionally, the PI will refine the genetic architecture of Lipoprotein(a), a protein encoded by a gene with a
VNTR whose length is known to influence cardiovascular disease risk.

## Key facts

- **NIH application ID:** 10774303
- **Project number:** 5K25HL150334-05
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Ronen Mukamel
- **Activity code:** K25 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $156,600
- **Award type:** 5
- **Project period:** 2020-02-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10774303

## Citation

> US National Institutes of Health, RePORTER application 10774303, Exploring the role of genomic repeats in cardiovascular disease heritability (5K25HL150334-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10774303. Licensed CC0.

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