# Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)

> **NIH NIH P30** · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2024 · $1,149,899

## Abstract

TEXAS BIOMED IN-TRAC OVERALL ABSTRACT
The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research
Institute (Texas Biomed) will attract the next generation of diverse researchers to the tuberculosis (TB) research
field, and develop them into independent researchers with multi-disciplinary skills and real-world experience of
clinical TB. The product of IN-TRAC will be researchers that choose to work on some of the most challenging
and relevant translational problems in TB, and that work across academic disciplines and within a framework of
highly collaborative research. This will be achieved through 6 interrelated Cores. Administrative Core: The
central hub of IN-TRAC management and oversight, with responsibility for administrative and scientific
leadership; coordinating communication between Cores, researchers and NIH/NIAID Program staff and
providing an organizational structure to optimize multidisciplinary collaborations and interactions between the
Cores and among a diverse cohort of IN-TRAC participants. Development Core: Oversight of all career
development programming and courses, tailoring the research and clinical experiences, both intern and
externships, to each individual IN-TRAC participant, and management of the IN-TRAC pilot grant program.
Biosafety & Biocontainment Core: Extending the required biosafety training to a personalized curriculum
including theoretical and hands-on biocontainment training, understanding the mechanical and regulatory
requirements of a BSL3/ABSL3, coaching on how to develop biosafety protocols, and working through risk
assessments from the perspective of a Biosafety Officer. Research Imaging Core: Providing theoretical and
hands-on training from single cell imaging (confocal microscopy, cytometry, live cell imaging, single cell RNAseq)
through to whole body imaging in mice (IVIS) and Non-human primates (NHP) (PET/CT) within large, fully
outfitted BSL3/ABSL3 facilities. Animal Model Core: Implementing a training program to introduce all IN-TRAC
participants to the regulatory requirements for working with rodents and NHPs, how to develop a robust
experimental protocol, how to write an IACUC protocol, and hands-on animal handling and experimental
procedures. Clinical Research & Patient Care Core: Introducing IN-TRAC participants to TB patient care at
the only free-standing TB hospital in the US (Texas Center of Infectious Diseases) that manages some of the
most challenging cases of TB nationally. Partnering with this will be a clinical research experience at the US-
Mexico border, to experience TB studies in under-served and under-resourced communities.

## Key facts

- **NIH application ID:** 10774308
- **Project number:** 5P30AI168439-03
- **Recipient organization:** TEXAS BIOMEDICAL RESEARCH INSTITUTE
- **Principal Investigator:** Larry S. Schlesinger
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,149,899
- **Award type:** 5
- **Project period:** 2022-03-10 → 2027-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10774308

## Citation

> US National Institutes of Health, RePORTER application 10774308, Interdisciplinary NexGen TB research Advancement Center (IN-TRAC) (5P30AI168439-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10774308. Licensed CC0.

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