# Tissue-Anchored vs. Circulating Engineered Enzyme Constructs for Immunometabolic Resolution of Psoriasis

> **NIH NIH R01** · UNIVERSITY OF FLORIDA · 2024 · $774,914

## Abstract

Project Summary/Abstract
We have developed innovative new approaches of administering immunotherapeutic enzymes
that robustly directs immune cells away from chronic inflammation toward homeostasis through
metabolic programming. Innovative fusion protein enzyme constructs in both tissue-anchored and
circulating forms are investigated, quantifying cellular mechanisms of action in order to determine
if different administration routes offer advantages. There is considerable need for new therapeutic
options for the chronic auto-inflammatory disease, psoriasis, which irreversibly damage epidermal
tissues.

## Key facts

- **NIH application ID:** 10774324
- **Project number:** 5R01AI171045-02
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Dorina Avram
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $774,914
- **Award type:** 5
- **Project period:** 2023-02-02 → 2028-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10774324

## Citation

> US National Institutes of Health, RePORTER application 10774324, Tissue-Anchored vs. Circulating Engineered Enzyme Constructs for Immunometabolic Resolution of Psoriasis (5R01AI171045-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10774324. Licensed CC0.

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