PROJECT SUMMARY/ABSTRACT Patient safety events are an important leading cause of morbidity and mortality globally; harm from patient safety events can be an important driver of health disparities. Black patients are at increased risk of patient safety events compared to White patients. Black patients also receive care at lower quality hospitals than White patients. In part this is due to the fact that in the US, hospital care is highly segregated with 25% of hospitals caring for 90% of elderly Black patients. Hospitals that care for a high proportion of Black patients are known as Black serving hospitals. Black serving hospitals perform worse on several Agency for Healthcare Research Quality (AHRQ) patient safety indicators including those at the individual-provider level, surgical related events, and hospital resource-dependent events. While higher patient safety events in Black serving hospitals is likely due to several factors, one area of research that has not been conducted is examining the differences in the culture of safety in Black serving versus non-Black serving hospitals. Evidence indicates that health systems with a robust patient safety culture have fewer adverse safety events. Disparities in patient safety culture may contribute to such inequities in patient safety in Black and non-Black serving hospitals. Given these gaps, we propose in response to AHRQ’s Special Emphasis Notice for Health Services Research to Advance Health Equity a mixed-methods study guided by Donabedian’s Quality Framework and the National Institute on Minority Health and Health Disparities Research Framework with the aims to: 1) Identify and compare patterns in patient safety culture for Black and non-Black serving hospitals; 2) Examine associations of patient safety culture with financial resources and with patient safety outcomes in Black and non-Black serving hospitals; and 3) Describe perceived facilitators and barriers that contribute to organizational support and promotion of patient safety and identify best patient safety practices for diverse settings. In Aim 1, we will use de-identified data from AHRQ’s Hospital Survey on Patient Safety Culture (HSOPS) to compare patient safety culture in Black and non-Black serving hospitals. In Aim 2, we will link Medicare, American Hospital Association, and other publicly available hospital characteristics datasets to identified HSOPS data to examine the association of patient safety culture with patient safety events (PSEs) and identify other factors associated with disparities in HSOPS and PSEs. In Aim 3, we will conduct group interviews with hospital leaders (financial executive, clinician, patient safety officer) in Black and non-Black serving hospitals to identify facilitators and barriers to effective patient safety culture practices and strategies to improve patient safety. Our work will identify root causes of disparities in patient safety, explore differences in barriers to health equity, and highlight be...