# Core A: Administrative Core

> **NIH NIH P01** · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $274,317

## Abstract

SUMMARY: CORE A- ADMINISTRATIVE CORE. The Administrative (Admin) Core will provide the leadership,
coordination, and administrative oversight to achieve the programmatic goals of the Harvard Aging Brain Study
(HABS) Program Project Grant (PPG). The Admin Core will strive to ensure optimal integration of the five
Cores and four research Projects of the HABS PPG renewal to achieve maximal scientific productivity. Aim 1:
The Admin Core is led by the Co-Principal Investigators (Sperling/Johnson) and will provide administrative and
scientific oversight of the PPG. The Admin Core, through the co-PIs of the PPG, will take primary responsibility
for ensuring scientific rigor and reproducibility across all aspects of the HABS PPG. The Core will coordinate
quarterly meetings of the Executive Committee and will convene in-person meetings of the External Scientific
Advisory Board (ESAB). Aim 2: The Admin Core will facilitate the efficient communication and integration
between all components of the PPG, provide oversight of timely data transfer from all Cores and Projects to
the Analytic Core to achieve maximal scientific productivity, and track all scientific presentations and
publications. Aim 3: The Admin Core will prepare NIH progress reports, interface with the Clinical Core to
prepare IRB documentation and annual continuing review, and with the Imaging Core to prepare annual
reports to the MGH Radioactive Drug Research Committee. Aim 4: The Admin Core will oversee all aspects of
the PPG finances to assure fiscal responsibility. Aim 5: The Admin Core will serve to coordinate PPG
interactions with institutional resources and programs, including the Massachusetts Alzheimer’s Disease
Research Center (MADRC), the Martinos Center for Biomedical Imaging at Massachusetts General Hospital
(MGH), and the MGH PET Core. Aim 6: The Admin Core will serve to facilitate collaborations between the
PPG and related scientific initiatives within Harvard and the larger scientific community, providing oversight of
the rapidly increasing number of requests for collaborations and data sharing. The Admin Core seeks to
enhance the coordination of an outstanding multidisciplinary group of investigators with a strong record of
collaboration and scientific productivity. The Admin Core will serve to maximize the knowledge gained from the
rich longitudinal data from the well-characterized HABS cohort to improve our understanding of the gradual
transition from normal aging to the earliest stages of preclinical Alzheimer’s disease (AD), and inform the
design and analytic strategies for ongoing and future prevention trials. Given the multitude of recent
disappointing results from clinical trials in the symptomatic stages of Alzheimer’s disease (AD), our continued
work to elucidate the impact of amyloid and tau pathology on the aging brain, and new research initiatives to
better understand the many factors that modulate cognitive decline, are more important than ever.

## Key facts

- **NIH application ID:** 10775718
- **Project number:** 5P01AG036694-14
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** REISA A. SPERLING
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $274,317
- **Award type:** 5
- **Project period:** 2010-07-15 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10775718

## Citation

> US National Institutes of Health, RePORTER application 10775718, Core A: Administrative Core (5P01AG036694-14). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10775718. Licensed CC0.

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