# Precision Functional Neuroimaging Core

> **NIH NIH P50** · UNIVERSITY OF ROCHESTER · 2024 · $342,494

## Abstract

Abstract: Functional neuroimaging experiments utilizing both resting state fMRI and task-based fMRI are 
proposed by individual projects across the Center, to accurately characterize the OCDnet. Given the 
substantial inter-individual variability of the OCDnet, these projects require advanced analytical approaches 
that can reliably and accurately map the OCD nodes in each participant. The central goal of the present core is 
to support these projects in acquiring and analyzing functional neuroimaging data using the cutting-edge 
techniques to achieve subject-level precision. Aim 1: The core will develop and implement individualized 
targeting strategies to identify homologous, subject-specific regions and networks based on resting-state fMRI. 
We will use a “maximizing between-subject homology” strategy and parcellate each subject's cerebral cortex 
into very fine-grained functional clusters, each of which may consist of a single region or of several discrete 
regions. We will also identify homologous hub regions in humans based on connectivity patterns observed in 
non-human primates (NHPs). Aim 2: The core will develop and implement highly innovative denoising 
technologies that will dramatically improve the SNR of both task-based fMRI and resting state fMRI data. The 
denoising technology will be key to obtaining reliable task-induced functional responses not only at the 
individual subject level but also at the single trial level. Aim 3: The core will assist projects in continuing to 
implement the advanced functional MRI neuroimaging protocols developed during the previous funding 
period, that maximize within-individual signal properties and minimize anatomical distortion.

## Key facts

- **NIH application ID:** 10778644
- **Project number:** 5P50MH106435-08
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **Principal Investigator:** Danhong Wang
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $342,494
- **Award type:** 5
- **Project period:** 2015-06-01 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10778644

## Citation

> US National Institutes of Health, RePORTER application 10778644, Precision Functional Neuroimaging Core (5P50MH106435-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10778644. Licensed CC0.

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