# Core-001

> **NIH NIH P01** · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $1,396,395

## Abstract

Nonhuman primates (NHP) specifically, rhesus macaques (RMs), are a key animal model in investigating 
prevention strategies of HIV infection. This animal model of simian immunodeficiency virus (SIV)/ simian-human
immunodeficiency virus (SHIV) infection has been utilized to elucidate both basic concepts in immunization and 
evaluate clinically relevant prevention approaches. RMs are ideal for investigating the humoral and cellular 
responses generated by HIV candidate immunizations and the impact on acquisition of infection. NHP studies 
require extensive coordination, expertise, personnel, and infrastructure. Therefore, the NHP Core (Core B) will 
support this HIVRAD research team by executing the four preclinical RM immunization studies proposed in 
Project 1. The animals will receive a variety of novel candidate immunogens and vaccine strategies. Their 
immune responses will be monitored throughout the study via collection of blood and tissues. Dependent upon 
those results, potentially, a select few animals will undergo viral challenge with SHIV to test the efficacy of the 
immunizations. Core B will support the success of this research program by 1) ensuring the adherence to 
regulatory approvals and procedures necessary for NHP research; 2) coordination of animal selection,
assignment, substance administration and sample collection; 3) proper storage and shipment of all samples to 
the collaborating PIs and Cores; 4) coordination of data collection, analysis, and distribution; 5) and ensuring the 
monitoring of animal health over the course of the studies. This NHP core will work closely with the collaborators 
for the vaccine and challenge studies and will participate actively in the scientific mission of this HIVRAD. Further, 
it will ensure that all NHP research is integrated with the goals of this proposal and the evolving needs of the 
studies. Core B is led by Dr. Guido Silvestri, who has >20 years of experience leading NHP research projects 
involving complex study design and intervention, specifically, he has executed a large number of collaborative 
pre-clinical vaccine trials. During this research he was essential in investigating and developing novel sample 
collection techniques, such as lymph node fine needle aspirates, for the continued monitoring of germinal center 
responses during longitudinal studies. Core B will be based at Yerkes National Primate Research Center 
(YNPRC) at Emory University, this NIH-funded primate research center possesses all the proper animal 
resources and state-of-the-art veterinarian care expertise necessary to support the proposed work. As an integral 
part of this research program, the NHP Core will provide critical support to achieve the shared objectives of 
evaluating these proposed promising novel pre-clinical vaccines.

## Key facts

- **NIH application ID:** 10782243
- **Project number:** 5P01AI157299-03
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** Richard Thomas Wyatt
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,396,395
- **Award type:** 5
- **Project period:** 2021-02-04 → 2026-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10782243

## Citation

> US National Institutes of Health, RePORTER application 10782243, Core-001 (5P01AI157299-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10782243. Licensed CC0.

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