# Transcriptional and epigenetic mechanisms of alveologenesis and re-alveologenesis

> **NIH NIH R35** · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $1,122,351

## Abstract

PROJECT SUMMARY
 Lung diseases impacting the gas exchange alveoli, including COVID-19, are becoming the leading cause
of death. A multi-lineage, transcriptional, and epigenetic understanding of alveologenesis and re-
alveologenesis upon injury is a timely response to the disease burden and leverages latest single-cell
technology. My lab’s track record in studying the lung epithelial, endothelial, and mesenchymal lineages lays
the foundation for pursuing a poorly understood process of cellular maturation (Theme 1), a recently identified
capillary cell type (Theme 2), and a novel signaling regulation of distinct mesenchymal cell populations (Theme
3). The anticipated knowledge will tackle fundamental questions of cell fate, plasticity, and signaling; shed light
on bronchopulmonary dysplasia, pulmonary hypertension, acute lung injury, as well as non-coding variants
from genome-wide association studies; and opens the door to single-cell functional genomics applicable to any
organ.

## Key facts

- **NIH application ID:** 10785543
- **Project number:** 1R35HL171346-01
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **Principal Investigator:** Jichao Chen
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,122,351
- **Award type:** 1
- **Project period:** 2024-03-15 → 2031-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10785543

## Citation

> US National Institutes of Health, RePORTER application 10785543, Transcriptional and epigenetic mechanisms of alveologenesis and re-alveologenesis (1R35HL171346-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10785543. Licensed CC0.

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