# Diversity Supplement-Massoudi

> **NIH NIH R33** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $106,768

## Abstract

PROJECT SUMMARY
Vascular cognitive impairment and dementia (VCID) is any level of cognitive alteration that is attributable to
cerebrovascular pathologies. VCID is second only to Alzheimer’s disease as a cause of dementia and accounts
for ~15-30% of all dementia cases. Cerebral small vessel diseases (cSVDs) are group of pathologies afflicting
the microcirculation of the brain that collectively account for up to 20% of all strokes and is the most common
pathology underlying VCID. The impact of cSVD and VCID is expected to increase rapidly as the population of
the US and other countries ages. Importantly, the pathogeneses of cSVDs are incompletely understood which
represents a major barrier in developing strategies for prevention and treatment. Research described in this
proposal will develop and validate five novel mouse models of cSVD based on genes and mutations that are
demonstrated to contribute to human disease. We have assembled an interdisciplinary team of experts that will
integrate unique genetic resources, vascular pressure myography, patch-clamp electrophysiology, calcium
imaging, specialized magnetic resonance imaging modalities and learning and memory behavior assays to
develop and characterize multiple novel genetic models of cSVD using genes that contribute to disease in
humans. Our long-term objective is to develop and employ genetic models that faithfully recapitulate important
hallmarks of human cSVD and VCID.

## Key facts

- **NIH application ID:** 10787059
- **Project number:** 3R33NS115132-04S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Myriam Marianne Chaumeil
- **Activity code:** R33 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $106,768
- **Award type:** 3
- **Project period:** 2019-09-18 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10787059

## Citation

> US National Institutes of Health, RePORTER application 10787059, Diversity Supplement-Massoudi (3R33NS115132-04S1). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10787059. Licensed CC0.

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