# Panretinal Circular Ranging OCT for Retinoblastoma

> **NIH NIH R21** · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $241,068

## Abstract

PROJECT SUMMARY
Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. Although retinoblastoma
is an aggressive cancer, early diagnosis and treatment may prevent visual impairment, and even improve
mortality rates. This is particularly relevant for children at risk for retinoblastoma due to family history of the
disease, which can be inherited in an autosomal dominant fashion. These children benefit fromea rly and frequent
screening evaluations. Currently, RB diagnosis and management remains largely dependent upon
ophthalmoscopic evaluation by expert clinicians. Ophthalmoscopy offers panretinal imaging, but suffers from a
poor sensitivity to sub-millimeter (subclinical) tumors and a limited ability to monitor treatment response.
Handheld optical coherence tomography (HH-OCT) offers the promise to address both of these needs, but
technical deficiencies in imaging speed and axial range severely limit is clinica l utility. Recent innovations in
circular-ranging methods, stretched-pulse mode-locked frequency comb lasers, and ultrawide handheld
microscopes open new avenues for clinically meaningful deployments of HH-OCT in the management of Rb. In
Aim 1, we will integrate these innovative technologies into a prototype instrument providing panretinal high-
resolution three-dimensional imaging. In Aim 2, we will perform pilot imaging studies in sedated children
undergoing RB screening. Study data will be used to assess the feasibility of panretinal imaging by HH-OCT in
sedated children, to quantify RPE and ILM visibility as an image quality metric predictive of the instrument’s
ability to detect subclinical tumors, and to confirm that the volume of all imaged tumors, regardless of size, can
be calculated.

## Key facts

- **NIH application ID:** 10789750
- **Project number:** 1R21EY035816-01
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Yifan Jian
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $241,068
- **Award type:** 1
- **Project period:** 2024-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10789750

## Citation

> US National Institutes of Health, RePORTER application 10789750, Panretinal Circular Ranging OCT for Retinoblastoma (1R21EY035816-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10789750. Licensed CC0.

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