# Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native People

> **NIH NIH R35** · UNIVERSITY OF COLORADO DENVER · 2023 · $295,271

## Abstract

Project Summary/Abstract
With the establishment of many large biobanks and consortia, and calls for increasing the diversity in
participants, it is imperative to develop robust evidence-based approaches to support the engagement of
diverse participants and to develop a proper bioethics-informed framework. The parent grant, entitled
“Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native (AIAN) People”, strives
to increase diversity in genomics research by developing a general model for research that engages all
communities. In this supplement, we enhance the ability to achieve this goal by recruiting members of
historically underrepresented communities to share perspectives on important bioethical issues related to
participant engagement, return of results, and data sharing. We will identify these individuals by recontacting
participants enrolled in the Colorado Center for Personalized Medicine (CCPM) Biobank research study at the
University of Colorado Anschutz Medical Campus, who have already consented to participate in genomics
research. Using mixed-methods and community-based participatory research frameworks, we aim to: 1)
Understand perspectives on participant engagement, return of results, and data sharing from historically
underrepresented participants (e.g., AIAN, African American, and Hispanic/Latino) in the CCPM Biobank with
focus groups and surveys; and 2) Develop a cross-site framework for assessing biobank participants
perspectives and engagement related to bioethical issues in biomedical research. The inclusion of African
American and Hispanic/Latino participants, in addition to AIAN communities, aligns with the parent grant goal
to equitably engage and build capacity for diverse communities. The CCPM Biobank offers an ideal population
for these activities, given its diverse and growing population, unique infrastructure that allows for quick
participant recontact, and successful reengagement with participants for research in recent years. Ultimately,
these evidence-building efforts are essential for the broader scientific community to develop culturally
informed, bioethical policies and frameworks around participant engagement, return of genomics research
results, and data sharing.

## Key facts

- **NIH application ID:** 10790627
- **Project number:** 3R35HG011319-04S1
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Katrina G Claw
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $295,271
- **Award type:** 3
- **Project period:** 2020-09-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10790627

## Citation

> US National Institutes of Health, RePORTER application 10790627, Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native People (3R35HG011319-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10790627. Licensed CC0.

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