# Recruiting multiethnic populations to preclinical Alzheimers disease trials-Diversity Supplement

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA-IRVINE · 2023 · $93,390

## Abstract

Abstract of Parent Research Project
Alzheimer’s disease (AD) and related dementias (ADRD) disproportionately affect underrepresented racial and
ethnic communities. The number of people with Alzheimer’s is expected to increase in the coming years, and
with this an increased burden to the public health system. To alleviate this, it is important to find treatments
through clinical trials that can slow disease progression, especially in diverse populations. Preclinical AD trials
lack diversity, and the trial requirements of learning one’s biomarker status and needing a study partner to enroll
could play a role. Our project focuses on understanding how the impact of these preclinical trial requirements,
biomarker disclosure and study partner requirement, differs among racial and ethnic groups. We will use
cognitive interviews to test our hypothesis that racial and ethnic groups differ in their willingness to learn
biomarker status. We will also use a previously developed assessment instrument1, to assess attitudes toward
the study partner requirement among diverse groups. We believe that the study partner requirement differentially
affects ability/willingness to participate among racial and ethnic groups. This work will help us collect data to
guide recruitment in preclinical AD trials in underrepresented groups, better understand attitudes toward
biomarker disclosure during the research process and understand the differences in attitudes toward the study
partner requirement so investigators can adjust to help underrepresented groups fill this role.

## Key facts

- **NIH application ID:** 10791432
- **Project number:** 3R21AG074371-02S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Joshua Grill
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $93,390
- **Award type:** 3
- **Project period:** 2022-08-15 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10791432

## Citation

> US National Institutes of Health, RePORTER application 10791432, Recruiting multiethnic populations to preclinical Alzheimers disease trials-Diversity Supplement (3R21AG074371-02S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10791432. Licensed CC0.

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