# Neurolinguistic development in 4 to 8 year-old late talkers with language delay > **NIH NIH R01** · VANDERBILT UNIVERSITY · 2024 · $663,109 ## Abstract PROJECT SUMMARY Late talking is associated with negative academic and socio-emotional outcomes. Despite this, behavioral measures are relatively poor at predicting who will end up having developmental language disorder. Moreover, not much is known about either the typical neurocognitive changes associated with language development or the brain basis of delayed language during preschool, as there have been only three retrospective studies. This project uses well-controlled functional neuroimaging paradigms tapping into receptive language skills and structural imaging of white matter connectivity, as well as an extensive behavioral battery that measures well- established deficits in phonology, semantics and morphology. Four-year-olds, oversampled for late talking, are longitudinally followed when they are 6- and 8-years-old. The first aim determines the sensitivity of the dorsal and ventral pathways to phonological and semantic skills, respectively, motivated by the predictions of the Dual Stream Theory. The second and third aim determine the strength of the directional effects of these pathways on each other, and whether these effects differ depending on age. The fourth aim determines the effect of these pathways on the behavioral development of morphology. Our finding that phonological processing drives the development of semantic and morphological processing would be consistent with Phonological Theory, that semantic processing drives the acquisition of phonological and morphological processing would be consistent with Semantic Theory, or that there are interactive effects would be consistent with Bidirectional Theory. Using a state-of-the-art analytical approach justified by tailored power analyses, we expect to find evidence supporting a model in which early phonological processing drives semantic change and later semantic processing drives morphological change. Although we have theoretically motivated planned comparisons, exploratory analyses will also be conducted to support future work. The scientific rigor of the project is supported by our extensive published research examining phonological and semantic specialization of the brain in kindergarteners into elementary school. The feasibility of the project is supported by our encouraging pilot behavioral and neuroimaging data in 4-year-olds on the exact paradigms to be used in this project. Although we take a dimensional approach to test our model, as research shows that language ability is on a continuum, we also perform exploratory categorical analyses comparing late talkers to typical children. Research is inconclusive with regards to the role of screening of language delay to inform decisions of early intervention. We hope that a more basic mechanistic understanding of the dynamics of language development will allow for the formulation of predictive biomarkers to be used in screening for intervention. We are committed to open science, and plan to pre-register our work, and share our ana... ## Key facts - **NIH application ID:** 10791749 - **Project number:** 5R01DC019787-02 - **Recipient organization:** VANDERBILT UNIVERSITY - **Principal Investigator:** James R Booth - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2024 - **Award amount:** $663,109 - **Award type:** 5 - **Project period:** 2023-03-01 → 2028-02-29 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10791749 ## Citation > US National Institutes of Health, RePORTER application 10791749, Neurolinguistic development in 4 to 8 year-old late talkers with language delay (5R01DC019787-02). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10791749. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*