# Neuropathology Core

> **NIH NIH P30** · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $172,409

## Abstract

Project Summary: Neuropathology Core!
The Neuropathology Core is aligned to support the overall specific aims of the OADC's 5 overarching aims: 1)
catalyze and sustain innovative research and discovery in AD and related disorders through an organizational
infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of
emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful
change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral
monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and
improving education and knowledge about dementia; 3) provide materials to support the science through well-
characterized research participants, biological specimens, brain tissue, data provision and analytics; 4)
contribute to the national research commons relevant to AD and related disorders; and 5) provide venues and
mechanisms for education and training of new scientists, as well as educating and informing key stakeholders.
The focus of the OADC’s Neuropathology Core on the transition from healthy aging to dementia has led to the
accumulation of a large repository of tissue from cognitively intact brain donors and from those who develop
dementia and milder impairments at a more advanced age, with pathologies that differ somewhat from those of
“classic” Alzheimer’s disease. Understanding these changes in the context of the clinical and imaging findings
in these individuals is proposed as the scientific “leitmotif” around which the Specific Aims are constructed.
These are to:
1. Provide standardized research assessments while at the same time affording this diagnostic expertise to
 the population of OADC subjects by providing family members of the deceased and physicians involved in
 their care with timely autopsy reports based on the most current standardized diagnostic criteria.
2. Facilitate research by collecting, storing and distributing a highly accessible, but appropriately safeguarded,
 repository of well-prepared brain tissue and neuropathologic data from carefully and longitudinally
 characterized patients with mild cognitive impairment (MCI) or dementia as well as non-cognitively impaired
 individuals using a variety of methods that maximizes utility to scientists.
3. Teach trainees in pathology, neurology, psychology, psychiatry, and basic sciences the current methods of
 neuropathological classification of neurodegenerative diseases and age-related changes, and mentor
 faculty in NP.
4. Develop innovative new approaches to maximize achievements in Aims 1 to 3.

## Key facts

- **NIH application ID:** 10791911
- **Project number:** 5P30AG066518-05
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Randall L Woltjer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $172,409
- **Award type:** 5
- **Project period:** 2020-07-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10791911

## Citation

> US National Institutes of Health, RePORTER application 10791911, Neuropathology Core (5P30AG066518-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10791911. Licensed CC0.

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