# Biomarker Core

> **NIH NIH P30** · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $92,172

## Abstract

Project Summary: Biomarker Core
The Biomarker Core is aligned to support the overall goals of the OADRC: To provide a structure and forum to
foster and develop new and innovative research in brain aging and the dementias, and to facilitate
collaborative research, scientific interactions, and data sharing transfer with other Alzheimer’s Disease
Centers, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Cooperative Study Unit, the
Alzheimer’s Consortium Treatment Consortium, the National Centralized Repository for Alzheimer’s Disease
and Related Dementias, and many other relevant outside research groups.
The mission of the OADRC’s Biomarker Core is to improve and maximize the quality and availability of
biomarker samples and information for research. It is organized to support current research, and to anticipate
future research requirements made possible by new knowledge and new technologies. The Specific Aims of
the Biomarker Core are as follows:
 1) To obtain and make available for research, biomarker specimens (DNA, plasma, and CSF) from
 OADRC subjects, including healthy control subjects, subjects with mild cognitive impairment (MCI), and
 subjects with AD and other dementias.
2) To obtain and make available for research, biomarker data on OADRC subjects. This will include: a)
 apolipoprotein E (ApoE) genotype on all subjects, b) single nucleotide polymorphism (SNP) profiles on
 select cohorts, c) genetic risk scores on select cohorts, and d) CSF Abeta, tau, and ptau values for
 OADRC subjects who donate CSF for research.
3) To foster collaborative research involving biomarkers and neurodegenerative disease. The areas of
 emphasis for the OADRC have been described in the overview as (a) Preclinical dementia and activity
 of disease emphasizing the oldest old; (b) Markers of meaningful change captured through studies of
 peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; (c)
 Neuropathology of brain aging and late life dementia; (d) Novel testing of novel treatments; and (e)
 Improving education and sharing knowledge about dementia. These areas will be priorities for the Core
 to support in collaborative work. In addition, the OADRC recognizes a responsibility to support all NIH-
 funded and comparably peer-reviewed research whenever possible.

## Key facts

- **NIH application ID:** 10791913
- **Project number:** 5P30AG066518-05
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** JOSEPH F QUINN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $92,172
- **Award type:** 5
- **Project period:** 2020-07-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10791913

## Citation

> US National Institutes of Health, RePORTER application 10791913, Biomarker Core (5P30AG066518-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10791913. Licensed CC0.

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