Project Summary/Abstract The occupational fatality rates in the Southeast region of the United States are 44% higher than the US fatality rate. In 2019, the overall occupational fatality rate for states in our region was 6.3 deaths/100,000 workers compared to 4.4/100,000 for the US overall, and higher in all individual states (Bureau of Labor Statistics) except Virginia. The goal of the Southeastern States Occupational Health Network (SouthON) collaborative working meetings over the next three years will be to continue to build upon the foundation we have established for regional occupational health surveillance (OHS) capacity and research in the 12-state Southeastern US region (Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, Virginia, and West Virginia). We will do this through: 1) continued strong regional partnerships and collaborations among state health departments, academic partners, internal National Institute for Occupational Safety and Health (NIOSH) researchers and surveillance experts, NIOSH-funded agricultural research centers and education research centers (ERCs), other governmental agencies, professional organizations, and occupational health and safety stakeholders; 2) data-driven development of occupational injury and illness research hypotheses; 3) southeastern occupational injury and illness surveillance and prevention activities; 4) state and southeast regional OHS capacity building; and 5) translation of occupational injury and illness research into public health practice. The objectives of our annual SouthON meetings are to: 1) develop common priorities for OHS epidemiological analyses, and worksite interventions; 2) build collaborations with other occupational epidemiologists, NIOSH, academic colleagues, Occupational Safety and Health Administration (OSHA), worker organizations, and other OHS partners; 3) provide epidemiology and program planning tools for OHS capacity building; and 4) promote scientific collaboration among OHS partners in the Southeast region. NIOSH funds will support the SouthON meeting participants.