# Biocontainment Research Support Service(s) Core

> **NIH NIH UC7** · UNIVERSITY OF CHICAGO · 2023 · $783,253

## Abstract

PROJECT ABSTRACT (Core 3/C3ResearchSupport@HTRL)
The Howard T. Ricketts Laboratory (HTRL) takes pride in its mission to provide a safe and secure environment
for cutting-edge Biodefense and Emerging Infectious Diseases research, under the support and supervision of
professionals with over 20 years of experience and under the umbrella of Core 3
(C3ResearchSupport@HTRL). The three aims of C3ResearchSupport@HTRL are to: (1) offer professional
research services for the isolation and characterization of a wide range of RG3/Select Agent pathogens (sub-
core C3Microbiology@HTRL); (2) offer professional research services in animal modelling of infection (sub-
core C3AnimalModels@HTRLB); (3) offer hands-on A/BSL3 training to Core 3 Users (sub-core
C3Training@HTRL). All these services will be advertised on the HTRL web page and will be rendered
following free consultation. C3ResearchSupport@HTRL draws on the extensive expertise of Drs. Ahmed and
Khader (Mycobacterium tuberculosis), Glenn Randall (RNA viruses) and Dominique Missiakas (Bacillus
anthracis, Yersinia pestis, Rickettsia sp.) at the University of Chicago. C3ResearchSupport@HTRL will
operate in collaboration with the RBL network, drawing on the expertise of 11 sister laboratories to provide
broad research support, implement contingency plans, and ensure a prompt response in the event of imminent
health threats to the nation. Briefly, C3Microbiology@HTRL will provide high-end technologies and expertise
toward the isolation and characterization of RG3 pathogens (biochemical, genetic, phenotypic
characterizations including antibiotic resistance profiles), the standardization of growth assays to test small
molecule inhibitors, the study of pathogen interactions with host cells. C3AnimalModels@HTRL will provide
standardized, high quality small animal models of infection for the development of countermeasures and for the
study of host responses. C3Training@HTRL will offer Users of Core 3 an opportunity to receive basic
instructions on biosafety, biosecurity, regulatory processes for the handling of high-risk pathogens, SOPs, and
safe laboratory practice in BSL3. C3ResearchSupport@HTRL aims to provide pristine expertise to support
research in response to new pandemics or biodefense threats on our nation or world-wide.

## Key facts

- **NIH application ID:** 10793952
- **Project number:** 1UC7AI180312-01
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Dominique Missiakas
- **Activity code:** UC7 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $783,253
- **Award type:** 1
- **Project period:** 2023-08-18 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10793952

## Citation

> US National Institutes of Health, RePORTER application 10793952, Biocontainment Research Support Service(s) Core (1UC7AI180312-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10793952. Licensed CC0.

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