# Emory/Georgia TB Research Advancement Center (TRAC)

> **NIH NIH P30** · EMORY UNIVERSITY · 2024 · $221,671

## Abstract

The Basic & Translational Science (Basic Science) Core of the Emory/Georgia TRAC will provide expertise
and resources to facilitate TRAC investigator-led studies of mycobacterial pathogenesis, transmission, and
host immunity in both human and animal models of Mycobacterium tuberculosis (Mtb) infection. The Basic
Science Core will capitalize on a unique set of resources available to the TRAC community, including the
Yerkes National Primate Research Center with capacity to conduct Mtb studies in rodents and nonhuman
primates, and the University of Georgia Animal Health Research Center with extensive animal BSL3 lab space
and capacity to conduct mycobacterial infection and vaccination studies in a variety of large, medium, and
small animals. The overall mission of the Basic Science Core is to provide laboratory expertise, training, and
resources to catalyze opportunities for innovative multidisciplinary and highly collaborative TB research
programs engaging Basic Science Core faculty, early-stage investigators, and established investigators who
are new to the TB field. The Core will achieve these goals by providing training, consultation, and services with
state-of-the-art laboratory equipment, facilities, and methods, including the newest immunological and
microbiological assays and animal Mtb infection models, in addition to providing a quality-controlled central
repository of materials for the TRAC community. In Aim 1, consultation in experimental design and laboratory
assay approaches will be provided to investigators who are planning basic and translational science studies of
Mtb. Specific training areas will include Mtb culture and in vitro infection; Mtb infection of animals; and lab
assay training, data interpretation, and protocol development. In Aim 2, the Core will provide support to TRAC
investigators to generate preliminary laboratory-based data for internal and external funding applications;
conduct laboratory assays and animal Mtb infection and vaccination studies in support of TRAC-series
Developmental awards and other funded projects; and support the development of new microbiology and
immunology laboratory-based assays. In Aim 3, a biorepository and electronic database will be established for
archiving clinical specimens and isolates from human cohorts across a range of Mtb infection and disease
states; specimens from Mtb-infected and control animals; and common Mtb laboratory strains for use by TRAC
investigators. In summary, the Basic Science Core will provide value-added activities in training, services, and
materials to Emory/Georgia TRAC investigators, with the overall goal of supporting TRAC investigators to
successfully establish and expand innovative research programs filling critical knowledge gaps in TB
pathogenesis, transmission, and immunity to more effectively combat the global TB pandemic.

## Key facts

- **NIH application ID:** 10794303
- **Project number:** 5P30AI168386-03
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Cheryl Liane Day
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $221,671
- **Award type:** 5
- **Project period:** 2022-03-23 → 2027-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10794303

## Citation

> US National Institutes of Health, RePORTER application 10794303, Emory/Georgia TB Research Advancement Center (TRAC) (5P30AI168386-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10794303. Licensed CC0.

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