# The Role of Inflammation in Regulating Gastric Metaplasia

> **NIH NIH R01** · SAINT LOUIS UNIVERSITY · 2024 · $534,362

## Abstract

ABSTRACT
The knowledge gaps this application addresses are how precancerous lesions (i.e. metaplasia) arise and
subsequently fuel adenocarcinoma of the stomach. Infection with Helicobacter pylori (H. pylori) and
autoimmune gastritis both cause chronic inflammation and increase the risk of gastric cancer. This application
includes numerous mouse models and human tissue samples to investigate the importance of immune cells
(mast cells and Th2 T cells) and cytokines (IL4 and IL13) in inducing gastric metaplasia and promoting the
development of gastric metaplasia and tumorigenesis. Identifying inflammatory cells and signals that initiate
metaplasia and drive tumor development could improve the ability to identify individuals at an increased risk of
disease progression, and new immune based strategies to prevent and treat preneoplastic lesions associated
with gastric diseases, including gastric cancer.

## Key facts

- **NIH application ID:** 10795008
- **Project number:** 5R01DK134531-02
- **Recipient organization:** SAINT LOUIS UNIVERSITY
- **Principal Investigator:** Richard J DiPaolo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $534,362
- **Award type:** 5
- **Project period:** 2023-03-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10795008

## Citation

> US National Institutes of Health, RePORTER application 10795008, The Role of Inflammation in Regulating Gastric Metaplasia (5R01DK134531-02). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10795008. Licensed CC0.

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