# Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure

> **NIH NIH R01** · ENDEAVOR HEALTH CLINICAL OPERATIONS · 2023 · $89,867

## Abstract

Each year, millions of people, including six million children, undergo general anesthesia
for surgeries, medical imaging, and other procedures. The potential negative effects of
anesthesia on the developing brain are concerning, as they may lead to later learning
and behavioral deficits. Currently, there are limited instrumental methods available for
diagnosing and predicting anesthesia-induced disabilities, as well as limited treatment
options. However, transcranial magnetic and electric stimulation (TMES) is an
established, non-invasive method that enables the assessment of the excitatory and
inhibitory properties of the brain. In addition to its diagnostic role, specific modalities of
TMES can produce long-lasting changes in local brain excitability by stimulating
neuronal plasticity and synaptogenesis. It is expected that TMES will aid in both
diagnosing and treating disabilities related to anesthesia exposure during childhood.

## Key facts

- **NIH application ID:** 10797738
- **Project number:** 3R01GM112715-07S1
- **Recipient organization:** ENDEAVOR HEALTH CLINICAL OPERATIONS
- **Principal Investigator:** Daniil Aksenov
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $89,867
- **Award type:** 3
- **Project period:** 2016-08-15 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10797738

## Citation

> US National Institutes of Health, RePORTER application 10797738, Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure (3R01GM112715-07S1). Retrieved via AI Analytics 2026-06-15 from https://api.ai-analytics.org/grant/nih/10797738. Licensed CC0.

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