# New York City Collaborative Regional Coordinating Center (NYCC-RCC)

> **NIH NIH U24** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $495,616

## Abstract

PROJECT SUMMARY/ABSTRACT
Stroke is a leading cause of disability and mortality with risk stratification based on socioeconomic status and race/ethnicity. The New York City Collaborative Regional Coordinating Center (NYCC-RCC) will unite three complementary research-intensive biomedical institutions (Einstein, NYU, Mount Sinai), three organizationally linked partners, and a network of high-volume clinical performance sites to further Stroke Net’s mission and to reduce the disproportionate burden of stroke in vulnerable and under-served populations. The NYCC-RCC has a record of leadership in community engagement and partnerships that will facilitate high-risk and under-studied patients’ enrollment in Stroke Net trials. The NYCC-RCC has significant expertise in the conception, development, and execution of clinical trials. The revamped NYCC-RCC will utilize a number of key design features to fulfill Stroke Net’s mission, including: 1) Organizational diversity through the integration of three leading academic health systems with targeted organizationally linked partners and clinical performance sites enhancing specific focus areas; 2) Recruitment and retention of underrepresented populations through com- munity engagement and strategic partnerships; 3) Focus on vulnerable pediatric stroke patients by integrating established pediatric stroke leadership with centers of excellence treating diseases known to confer high stroke risk; 4) Coordination of multiple high-volume thrombectomy centers to facilitate STEP platform enroll- ment; 5) Establishment of programs/infrastructure to facilitate hyper-acute stroke trial participation; 6) Comple- mentary, multidimensional MPI structure including an imbedded career development program; 7) A structured trial development process coupled with senior trialist guidance to generate a pipeline of Stroke Net trial sub- missions; 8) Pre-clinical expertise in evolving translational areas, including epigenetic and regenerative/stem cell therapeutic applications; 9) RCC connectivity via an advanced information technology and network perfor- mance group (IT/NPG). The NYCC-RCC will employ an integrated mentorship model to ensure career devel- opment of promising stroke investigators, including a structured education plan for StrokNet fellows utilizing the breadth and sophistication of our CTSA’s educational curriculums. The NYCC-RCC will train junior and mid-career investigators, as well as clinical research coordinators, toward productive careers in stroke re- search. In summary, the NYCC-RCC will leverage established clinical trials expertise with extensive scientific and organizational excellence to fulfill the Stroke Net’s mission. Therefore, this proposal seeks funding for an NIH Stroke Net – Regional Coordinating Stroke Center U24 – RFA-NS-23-010.

## Key facts

- **NIH application ID:** 10797886
- **Project number:** 1U24NS135391-01
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Aaron Sylvan Lord
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $495,616
- **Award type:** 1
- **Project period:** 2023-12-12 → 2028-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10797886

## Citation

> US National Institutes of Health, RePORTER application 10797886, New York City Collaborative Regional Coordinating Center (NYCC-RCC) (1U24NS135391-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10797886. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*