# Administrative Supplement: Post-transcriptional mechanisms of centrosome regulation

> **NIH NIH R01** · EMORY UNIVERSITY · 2023 · $64,547

## Abstract

Project Summary
Centrosome deregulation is the leading cause of heritable microcephaly, a congenital birth defect typically
associated with intellectual disabilities and developmental delay. Centrosome dysfunction is also considered a
key driver and prognostic marker of cancer. Yet, mechanisms underlying centrosome regulation remain
incompletely understood. Centrosomes undergo cell cycle-dependent changes in composition and organization
to modulate their activity as microtubule-organizing centers, and these oscillations contribute to the diversity of
centrosome functions. One dynamic constituent of centrosomes is mRNA, yet the functional role of mRNA
localized to centrosomes remains poorly understood. In this proposal, we examine whether mRNA contributes
to centrosome regulation and functions. In Aim 1, we define mechanisms of mRNA localization to
centrosomes. In Aim 2, we uncover the regulatory contributions of two conserved RNA-binding proteins. Aim 3
examines the function of mRNA localized to centrosomes. The completion of this work will address long-
standing questions about the role of mRNA localized to centrosomes within a genetically tractable model. This
work will contribute to our understanding of centrosome regulation, aspects of which are deregulated in cases
of microcephaly and cancer.

## Key facts

- **NIH application ID:** 10798587
- **Project number:** 3R01GM138544-04S1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Dorothy A Lerit
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $64,547
- **Award type:** 3
- **Project period:** 2020-08-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10798587

## Citation

> US National Institutes of Health, RePORTER application 10798587, Administrative Supplement: Post-transcriptional mechanisms of centrosome regulation (3R01GM138544-04S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10798587. Licensed CC0.

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